238000007635 classification algorithm Methods 0.000 claims description 6.238000010801 machine learning Methods 0.000 claims description 7.238000004422 calculation algorithm Methods 0.000 claims description 62.239000011824 nuclear material Substances 0.000 claims abstract description 26.210000004940 Nucleus Anatomy 0.000 claims abstract description 303.238000010191 image analysis Methods 0.000 title description 18.210000003855 Cell Nucleus Anatomy 0.000 title claims description 37.239000000463 material Substances 0.000 title claims abstract description 124.210000001519 tissues Anatomy 0.000 title claims abstract description 128.210000000805 Cytoplasm Anatomy 0.000 title claims abstract description 228.Assignors: LOS ALAMOS NATIONAL SECURITY, LLC Status Expired - Fee Related legal-status Critical Current Adjusted expiration legal-status Critical Links Publication of US20100111396A1 publication Critical patent/US20100111396A1/en Application granted granted Critical Publication of US8488863B2 publication Critical patent/US8488863B2/en Assigned to TRIAD NATIONAL SECURITY, LLC reassignment TRIAD NATIONAL SECURITY, LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Application filed by Los Alamos National Security LLC filed Critical Los Alamos National Security LLC Priority to US12/266,450 priority Critical patent/US8488863B2/en Assigned to LOS ALAMOS NATIONAL SECURITY, LLC reassignment LOS ALAMOS NATIONAL SECURITY, LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Original Assignee Los Alamos National Security LLC Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.) Boucheron Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Expired - Fee Related, expires Application number US12/266,450 Other versions US20100111396A1
Google Patents Combinational pixel-by-pixel and object-level classifying, segmenting, and agglomerating in performing quantitative image analysis that distinguishes between healthy non-cancerous and cancerous cell nuclei and delineates nuclear, cytoplasm, and stromal material objects from stained biological tissue materialsÄownload PDF Info Publication number US8488863B2 US8488863B2 US12/266,450 US26645008A US8488863B2 US 8488863 B2 US8488863 B2 US 8488863B2 US 26645008 A US26645008 A US 26645008A US 8488863 B2 US8488863 B2 US 8488863B2 Authority US United States Prior art keywords image objects biological tissue delineated pixels Prior art date Legal status (The legal status is an assumption and is not a legal conclusion.
Google Patents US8488863B2 - Combinational pixel-by-pixel and object-level classifying, segmenting, and agglomerating in performing quantitative image analysis that distinguishes between healthy non-cancerous and cancerous cell nuclei and delineates nuclear, cytoplasm, and stromal material objects from stained biological tissue materials
US8488863B2 - Combinational pixel-by-pixel and object-level classifying, segmenting, and agglomerating in performing quantitative image analysis that distinguishes between healthy non-cancerous and cancerous cell nuclei and delineates nuclear, cytoplasm, and stromal material objects from stained biological tissue materials